ࡱ> JLI[ RX bjbj22ΐΐJ DD8,(!!!!!Uo {[(](](](](](]($*D-v(#UU##(!!4(U%U%U%#H!![(U%#[(U%U%''! žL)%'G((0(',-)%-'-'xjpU%]Q((?%(####-D S: Curriculum Vitae Name: Nanguang Chen Address: 9 Engineering Dr. 1, # EA-03-12, Singapore 117576 Phone: +65 6516-4401 Email: biecng@nus.edu.sg Professional Positions Current position: Aug. 2004 - Assistant Professor, Division of Bioengineering, Faculty of Engineering, National University of Singapore. Previous employment: Jan 2002 - Aug 2004 Assistant Research Professor, Department of Electrical and Computer Engineering, University of Connecticut. Feb 2000 - Dec 2001 Postdoctoral Fellow, Department of Electrical and Computer Engineering, University of Connecticut. Sep 1994 Feb 1997 Lecturer, Department of Physics, Hunan Normal University. Jul 1988 Jul 1991 Instrumentation Engineer, Hunan Detergent Factory. Fellowship Feb. 2000 Jan.2002 Postdoctoral Fellow, Department of Electrical and Computer Engineering, University of Connecticut. Education 2000 Ph. D. in Biomedical Engineering, Department of Electrical Engineering, Tsinghua University. 1994 M. S. in Theoretical Physics, Department of Physics, Peking University. 1988 B. S. in Electrical Engineering, Department of Electrical Engineering, Hunan University. TEACHING EXPERIENCES: Graduate Courses Taught at the University of Connecticut: Biomedical Instrumentation (BME354) Bioinstrumentation (BME311) Graduate Course Taught at the National University of Singapore Engineering Principles in Medicine (BN5102) Undergraduate Course Taught at the National University of Singapore Biomedical Electronic Devices and Systems (BN3401) Biophotonics & Bioimaging (BN4406) Undergraduate Courses Taught at Hunan Normal University Fundamental of Microcomputers; Electrical and Electronics Circuits; Automatic Control Theory and Devices; Principles of Digital Communications; Microwave Technology and Antenna. PhD students supervised: LIU Linbo, MO Weirong, XU Yingshun, Wong Chee Howe (degree conferred) Zhang Qiang (Thesis submitted) Chen Ling, Chong Shau Poh, Kalpesh Mehta, Ali Hasnain, Soo Kee Seng Awards and Honors 2004 Young Investigator Award, Office of Life Science/National University of Singapore. 2001 Postdoctoral Training Award, Department of Defense Breast Cancer Research Program of the US Army Medical Research and Materiel Command. 2001 Excellent Ph. D. Dissertation Award, Tsinghua University. Patents 1. US Patent: Rotary Mirror Array for Fast Optical Tomography by Chen, N.G. and Zhu, Q. (US 6813050) 2. Fluorescence focal modulation microscopy system and method (International patent application No. PCT/SG2008/000240, US application No. 12/667,782) by Chen, N. G., Wong, C. H., and Sheppard, C. J. R. This invention has led to a multi-million-dollar licensing deal with a global leading company in optoelectronic industry. 3. US Provisional Application No. 61/323,938: Laplace Domain Optical Measurement Method by Chen N. G. Grants NRF Prove of Concept: PI, Line Scan Focal Modulation Microscope, 2010-2012 (S$220,300 direct cost). SERC TSRP: Co-PI, Novel Fano-Type and Asymmetric Metallic Nanostructures for Non-Intrusive In Vivo Imaging and Monitoring, 2010-2013 (S$557,668 direct cost). SBIC/SSCC: PI, Novel insight into basic problems of stem cell biology through live imaging of neuronal stem cells using Focal Modulation Microscopy, 2008-2011 (S$1M direct cost) SERC/A*STAR: PI, Pseudo-random single photon counting for time-resolved optical spectroscopy and imaging, 2006-2009 (S$635,140). SERC/A*STAR: Co-PI, New methods for fabricating nanoarray device, 2005-2008 (S$698,745). OLS/NUS: PI, Optical Mammography for Breast Cancer Early Detection, 2005-2008 (S$200,000). FRC/NUS: PI, Real-Time In Vitro Dual-Mode Imaging for Tissue Engineering, 2005-2008 (S$82,500). DoD: PI, Ultrasound Assisted Optical Imaging, DAMD17-01-1-0216; 2001-2004 Donaghue Medical Research Foundation: Co-Investigator, 3D simultaneous Ultrasound and Near Infrared Diffusive Imaging for Breast Cancer Detection, (2001-2004) NIH: Co-Investigator, Near Infrared Diffused Light Imaging with Ultrasound Guidance. (2001-2004) Multi-Dimension Technology: PI, Frequency-domain Diffuse Optical Imaging for Breast Cancer Detection. (2004) Professional Association Membership Society of Photo-Optical Instrumentation Engineers (SPIE) Optical Society of America (OSA) Novel Approaches Towards In-Vivo Biomedical Optical Imaging Abstract: Optical microscopes have been an indispensible tool for biological research and clinical applications. Many important breakthroughs in this field enable researchers to observe microscopic structures and functions that are not visible with conventional techniques. For example, optical coherence tomography (OCT) can provide a penetration depth up to a few millimeters by the use of coherence gating; Multi-photon microscopy (MPM) uses ultra-short laser pulses to achieve selective excitation and an imaging depth up to 700 microns. We have been developing a fluorescence microscopy method, Focal Modulation Microscopy, that offers a penetration depth comparable to OCT and MPM, while compatible with most fluorescence dyes and multiple contrast mechanisms. Preliminary experiments have demonstrated the feasibility of our approach and improved image quality over conventional confocal microscopy for deep tissue imaging. Non-invasive optical imaging of large human organs, such as human brain and breast, is desirable for disease diagnosis and treatment monitoring. However, human soft tissues are highly scattering for visible and near-infrared light. We are interested in time-resolved diffuse optical tomography (DOT), a technique that is based on measuring the pathlength resolved diffusive light intensity on tissue surfaces We have developed a novel approach to implement fast measurement with high signal to noise ratio. A prototype time-resolved DOT system has been built and characterized with phantom experiments. Preliminary studies with healthy human subjects were conducted and the results will serve as the baseline for future clinical experiments with breast cancer patients. More recently, a Laplace-domain DOT method has been proposed. 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