Abstract: A decoupling control strategy is proposed for looper strong coupling control system of hot strip rolling. Based on predictive control theory, a double-inputs-double-outputs control system could be divided into two SISO subsystems, the controller of each subsystem be updated sequentially in a sampling time, and the future control information be kept and used to compensate the coupling effect among subsystems. Control theory is used to reject error disturbance between the future control information and actual value. Above decoupling control strategy could simplify the design of controller, reduce computation load and improve control precision. Finally, simulation results show that the proposed control strategy has better decoupling and control performance.