Abstract: Simulation of the chemical processing of the methyl tert-butyl ether (MTBE) 80 000 tons/year plant for a petrochemical company was studied by using the process system simulation platform. The mathematical model of the MTBE process was established. The distributed control systems configuration and the score configuration were developed. The simulation training system software of the MTBE process was established. Combination accidents were established by using the safety analysis and training support system. The workers learn the MTBE process and the accident treatment of the production process by using this simulation training system. The operation sequence and operating quality of the trainees were assessed by using this simulation training system. At present, the MTBE plant simulation training system has been assessed and accepted by the petrochemical company. The MTBE plant simulation training system can be used to train workers and study the MTBE chemical processing.