Synthesis of N Acetyl 5 Methoxytryptamine

Aim To study and modify the synthesis method of melatonine. Methods Michael reaction was carried out with diethyl malonate and acrylonitrile used as starting materials. Then above reaction product was electro catalytically reduced to 2 oxopiperidine 3 carboxylate at 2 5 A/dm 2 with Raney Ni used as catalytically active powder electrode in the presence of methanol. Next,after diazotisation, Fischer indolization,ring opening and decarboxylation of carboline, and carbonylation reactions, the aim product N acetyl 5 methoxytryptamine was obtained. Results and Conclusion The 90% yield is obtained when 2 cyanoethyl diethyl malonate is reduced with the electrocatalytic method. Hydrogenating of high pressure condition is avoided in the electrocatalytic reduction process of cyano group to amino group. The over all yield of melatonine by above method is 25%.