Covalent Organic Framework Membranes for Enhanced Gas Dissolution in Oxygenation

Dafei Sheng; Xinlin Li; Shuang Zhao; Chao Sun; Qianli Ma; Xiao Feng; Bo Wang

doi:10.1021/jacs.5c06822

Covalent Organic Framework Membranes for Enhanced Gas Dissolution in Oxygenation

Dafei Sheng
, Xinlin Li
, Shuang Zhao
, Chao Sun
, Qianli Ma
, Xiao Feng^*
, Bo Wang^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Membrane-mediated gas-to-liquid mass transfer is crucial for chemical reactions and biological processes, yet low gas solubility in water limits exchange efficiency. To address this challenge, we leverage periodic, hydrophilic gradient nanochannels in highly oriented covalent organic framework (COF) membranes. These membranes exhibit a significantly higher oxygen dissolution rate than macroporous membranes with greater gas permeability, driven by nanoconfinement effects and increased liquid meniscus curvature, which reduce the hydrogen bond density and lower the oxygen–water binding energy. The engineered COF membrane achieves an unprecedented O₂ transfer rate of 2838 mL m^–2 min^–1 to blood, 11 times higher than that of the conventional oxygenation membrane, poly(4-methyl-1-pentene), while offering comparable blood compatibility and anticoagulant properties, along with a reduced risk of gas embolism.

Original language	English
Pages (from-to)	24838-24846
Number of pages	9
Journal	Journal of the American Chemical Society
Volume	147
Issue number	28
DOIs	https://doi.org/10.1021/jacs.5c06822
Publication status	Published - 16 Jul 2025
Externally published	Yes

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title = "Covalent Organic Framework Membranes for Enhanced Gas Dissolution in Oxygenation",

abstract = "Membrane-mediated gas-to-liquid mass transfer is crucial for chemical reactions and biological processes, yet low gas solubility in water limits exchange efficiency. To address this challenge, we leverage periodic, hydrophilic gradient nanochannels in highly oriented covalent organic framework (COF) membranes. These membranes exhibit a significantly higher oxygen dissolution rate than macroporous membranes with greater gas permeability, driven by nanoconfinement effects and increased liquid meniscus curvature, which reduce the hydrogen bond density and lower the oxygen–water binding energy. The engineered COF membrane achieves an unprecedented O2 transfer rate of 2838 mL m–2 min–1 to blood, 11 times higher than that of the conventional oxygenation membrane, poly(4-methyl-1-pentene), while offering comparable blood compatibility and anticoagulant properties, along with a reduced risk of gas embolism.",

author = "Dafei Sheng and Xinlin Li and Shuang Zhao and Chao Sun and Qianli Ma and Xiao Feng and Bo Wang",

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T1 - Covalent Organic Framework Membranes for Enhanced Gas Dissolution in Oxygenation

AU - Sheng, Dafei

AU - Li, Xinlin

AU - Zhao, Shuang

AU - Sun, Chao

AU - Ma, Qianli

AU - Feng, Xiao

AU - Wang, Bo

PY - 2025/7/16

Y1 - 2025/7/16

N2 - Membrane-mediated gas-to-liquid mass transfer is crucial for chemical reactions and biological processes, yet low gas solubility in water limits exchange efficiency. To address this challenge, we leverage periodic, hydrophilic gradient nanochannels in highly oriented covalent organic framework (COF) membranes. These membranes exhibit a significantly higher oxygen dissolution rate than macroporous membranes with greater gas permeability, driven by nanoconfinement effects and increased liquid meniscus curvature, which reduce the hydrogen bond density and lower the oxygen–water binding energy. The engineered COF membrane achieves an unprecedented O2 transfer rate of 2838 mL m–2 min–1 to blood, 11 times higher than that of the conventional oxygenation membrane, poly(4-methyl-1-pentene), while offering comparable blood compatibility and anticoagulant properties, along with a reduced risk of gas embolism.

AB - Membrane-mediated gas-to-liquid mass transfer is crucial for chemical reactions and biological processes, yet low gas solubility in water limits exchange efficiency. To address this challenge, we leverage periodic, hydrophilic gradient nanochannels in highly oriented covalent organic framework (COF) membranes. These membranes exhibit a significantly higher oxygen dissolution rate than macroporous membranes with greater gas permeability, driven by nanoconfinement effects and increased liquid meniscus curvature, which reduce the hydrogen bond density and lower the oxygen–water binding energy. The engineered COF membrane achieves an unprecedented O2 transfer rate of 2838 mL m–2 min–1 to blood, 11 times higher than that of the conventional oxygenation membrane, poly(4-methyl-1-pentene), while offering comparable blood compatibility and anticoagulant properties, along with a reduced risk of gas embolism.

UR - https://www.scopus.com/pages/publications/105009587680

U2 - 10.1021/jacs.5c06822

DO - 10.1021/jacs.5c06822

M3 - Article

C2 - 40601884

AN - SCOPUS:105009587680

SN - 0002-7863

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 28

ER -

Covalent Organic Framework Membranes for Enhanced Gas Dissolution in Oxygenation

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