Application of Biosensors Based on Covalent Organic Frameworks, Metal-Organic Frameworks, and their Composites in Biomedical Detection

Hewen Chen; Ziyu Zhu; Tianjian Lv; Qian Yang; Shan Nan; Zikai Hao; Bingteng Xie; Aiqin Luo; Axin Liang

doi:10.1007/s41664-025-00407-5

Application of Biosensors Based on Covalent Organic Frameworks, Metal-Organic Frameworks, and their Composites in Biomedical Detection

Hewen Chen
, Ziyu Zhu
, Tianjian Lv
, Qian Yang
, Shan Nan
, Zikai Hao
, Bingteng Xie^*
, Aiqin Luo^*
, Axin Liang^*

^*此作品的通讯作者

Beijing Institute of Technology

科研成果: 期刊稿件 › 文献综述 › 同行评审

11 引用（Scopus）

摘要

Covalent Organic Frameworks (COFs) and Metal-Organic Frameworks (MOFs), as novel porous crystalline materials, have demonstrated unique advantages in the field of biomedical detection in recent years. This study provides a concise overview of design strategies for biosensors based on COFs and MOFs, as well as their complexes. It also highlights the latest applications of these biosensors in the detection of microorganisms, nucleic acids, small molecules, and protein biomarkers. Through specific case studies, the roles and sensing mechanisms of these porous framework materials in various innovative designs are explored. Finally, based on novel COFs, MOFs, and MOF/COF composites in biomedical detection applications, this study synthesizes and deliberates on the challenges and future directions of biological and chemical sensors.

源语言	英语
页（从-至）	25-57
页数	33
期刊	Journal of Analysis and Testing
卷	10
期	1
DOI	https://doi.org/10.1007/s41664-025-00407-5
出版状态	已出版 - 3月 2026
已对外发布	是

访问文件

10.1007/s41664-025-00407-5

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{f778591060784cbca9fa2fefad5a6eeb,

title = "Application of Biosensors Based on Covalent Organic Frameworks, Metal-Organic Frameworks, and their Composites in Biomedical Detection",

abstract = "Covalent Organic Frameworks (COFs) and Metal-Organic Frameworks (MOFs), as novel porous crystalline materials, have demonstrated unique advantages in the field of biomedical detection in recent years. This study provides a concise overview of design strategies for biosensors based on COFs and MOFs, as well as their complexes. It also highlights the latest applications of these biosensors in the detection of microorganisms, nucleic acids, small molecules, and protein biomarkers. Through specific case studies, the roles and sensing mechanisms of these porous framework materials in various innovative designs are explored. Finally, based on novel COFs, MOFs, and MOF/COF composites in biomedical detection applications, this study synthesizes and deliberates on the challenges and future directions of biological and chemical sensors.",

keywords = "Biomedical detection, Biosensor, MOF/COF composites, Metal-organic frameworks",

author = "Hewen Chen and Ziyu Zhu and Tianjian Lv and Qian Yang and Shan Nan and Zikai Hao and Bingteng Xie and Aiqin Luo and Axin Liang",

note = "Publisher Copyright: {\textcopyright} The Nonferrous Metals Society of China 2025.",

year = "2026",

month = mar,

doi = "10.1007/s41664-025-00407-5",

language = "English",

volume = "10",

pages = "25--57",

journal = "Journal of Analysis and Testing",

issn = "2096-241X",

publisher = "Springer International Publishing",

number = "1",

}

TY - JOUR

T1 - Application of Biosensors Based on Covalent Organic Frameworks, Metal-Organic Frameworks, and their Composites in Biomedical Detection

AU - Chen, Hewen

AU - Zhu, Ziyu

AU - Lv, Tianjian

AU - Yang, Qian

AU - Nan, Shan

AU - Hao, Zikai

AU - Xie, Bingteng

AU - Luo, Aiqin

AU - Liang, Axin

N1 - Publisher Copyright: © The Nonferrous Metals Society of China 2025.

PY - 2026/3

Y1 - 2026/3

N2 - Covalent Organic Frameworks (COFs) and Metal-Organic Frameworks (MOFs), as novel porous crystalline materials, have demonstrated unique advantages in the field of biomedical detection in recent years. This study provides a concise overview of design strategies for biosensors based on COFs and MOFs, as well as their complexes. It also highlights the latest applications of these biosensors in the detection of microorganisms, nucleic acids, small molecules, and protein biomarkers. Through specific case studies, the roles and sensing mechanisms of these porous framework materials in various innovative designs are explored. Finally, based on novel COFs, MOFs, and MOF/COF composites in biomedical detection applications, this study synthesizes and deliberates on the challenges and future directions of biological and chemical sensors.

AB - Covalent Organic Frameworks (COFs) and Metal-Organic Frameworks (MOFs), as novel porous crystalline materials, have demonstrated unique advantages in the field of biomedical detection in recent years. This study provides a concise overview of design strategies for biosensors based on COFs and MOFs, as well as their complexes. It also highlights the latest applications of these biosensors in the detection of microorganisms, nucleic acids, small molecules, and protein biomarkers. Through specific case studies, the roles and sensing mechanisms of these porous framework materials in various innovative designs are explored. Finally, based on novel COFs, MOFs, and MOF/COF composites in biomedical detection applications, this study synthesizes and deliberates on the challenges and future directions of biological and chemical sensors.

KW - Biomedical detection

KW - Biosensor

KW - MOF/COF composites

KW - Metal-organic frameworks

UR - https://www.scopus.com/pages/publications/105024121453

U2 - 10.1007/s41664-025-00407-5

DO - 10.1007/s41664-025-00407-5

M3 - Review article

AN - SCOPUS:105024121453

SN - 2096-241X

VL - 10

SP - 25

EP - 57

JO - Journal of Analysis and Testing

JF - Journal of Analysis and Testing

IS - 1

ER -

Application of Biosensors Based on Covalent Organic Frameworks, Metal-Organic Frameworks, and their Composites in Biomedical Detection

摘要

访问文件

其它文件与链接

学术指纹

引用此