Aptamer-engineered SERS sensors: Molecular recognition meets plasmonic enhancement for precision detection

Xu Fan; Ziwen Zhang; Zhuoting Liu; Ying Ying Cao; Taojing Zhang; Baofang Feng; Fei Liu; Feng Qu; Shenghang Zhang; Weidong Zhao; Jian Sun; Tie Wang

doi:10.1016/j.trac.2026.118664

Aptamer-engineered SERS sensors: Molecular recognition meets plasmonic enhancement for precision detection

Xu Fan
, Ziwen Zhang
, Zhuoting Liu
, Ying Ying Cao
, Taojing Zhang
, Baofang Feng
, Fei Liu
, Feng Qu
, Shenghang Zhang^*
, Weidong Zhao^*
, Jian Sun^*
, Tie Wang^*

^*此作品的通讯作者

生命学院

Beijing Institute of Technology
Fujian University of Traditional Chinese Medicine
Fujian Provincial Hospital
Tianjin University of Technology

科研成果: 期刊稿件 › 文献综述 › 同行评审

4 引用（Scopus）

摘要

Surface-enhanced Raman spectroscopy (SERS) is a powerful technique with high sensitivity, fast response, and non-destructive detection, but it faces interference from other substances in practical applications. Aptamers, as excellent affinity agents, have the capability to bind with various targets to form stable structures. The integration of aptamers into SERS sensors can significantly enhance the acquisition and selection of target objects, thereby enabling the detection of various functional molecules. In this review, we describe the mechanisms of SERS enhancement and the construction of SERS substrates. We summarize the design strategies for aptamer-based SERS technology and provide an overview of its applications in environmental pollutant detection, food safety and quality monitoring, and biomedical diagnostics. Finally, we discuss the current advantages and limitations of aptamer-based SERS sensors, as well as the vast potential for future development. This review will provide a guiding route for the development and application of novel aptamer-based sensors.

源语言	英语
期刊论文编号	118664
期刊	TrAC - Trends in Analytical Chemistry
卷	196
DOI	https://doi.org/10.1016/j.trac.2026.118664
出版状态	已出版 - 3月 2026

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title = "Aptamer-engineered SERS sensors: Molecular recognition meets plasmonic enhancement for precision detection",

abstract = "Surface-enhanced Raman spectroscopy (SERS) is a powerful technique with high sensitivity, fast response, and non-destructive detection, but it faces interference from other substances in practical applications. Aptamers, as excellent affinity agents, have the capability to bind with various targets to form stable structures. The integration of aptamers into SERS sensors can significantly enhance the acquisition and selection of target objects, thereby enabling the detection of various functional molecules. In this review, we describe the mechanisms of SERS enhancement and the construction of SERS substrates. We summarize the design strategies for aptamer-based SERS technology and provide an overview of its applications in environmental pollutant detection, food safety and quality monitoring, and biomedical diagnostics. Finally, we discuss the current advantages and limitations of aptamer-based SERS sensors, as well as the vast potential for future development. This review will provide a guiding route for the development and application of novel aptamer-based sensors.",

keywords = "Aptamer, Molecular recognition, Plasmonic nanostructure, Sensors, Surface-enhanced Raman spectroscopy (SERS)",

author = "Xu Fan and Ziwen Zhang and Zhuoting Liu and Cao, \{Ying Ying\} and Taojing Zhang and Baofang Feng and Fei Liu and Feng Qu and Shenghang Zhang and Weidong Zhao and Jian Sun and Tie Wang",

note = "Publisher Copyright: {\textcopyright} 2026 Elsevier B.V.",

year = "2026",

month = mar,

doi = "10.1016/j.trac.2026.118664",

language = "English",

volume = "196",

journal = "TrAC - Trends in Analytical Chemistry",

issn = "0165-9936",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Aptamer-engineered SERS sensors

T2 - Molecular recognition meets plasmonic enhancement for precision detection

AU - Fan, Xu

AU - Zhang, Ziwen

AU - Liu, Zhuoting

AU - Cao, Ying Ying

AU - Zhang, Taojing

AU - Feng, Baofang

AU - Liu, Fei

AU - Qu, Feng

AU - Zhang, Shenghang

AU - Zhao, Weidong

AU - Sun, Jian

AU - Wang, Tie

PY - 2026/3

Y1 - 2026/3

N2 - Surface-enhanced Raman spectroscopy (SERS) is a powerful technique with high sensitivity, fast response, and non-destructive detection, but it faces interference from other substances in practical applications. Aptamers, as excellent affinity agents, have the capability to bind with various targets to form stable structures. The integration of aptamers into SERS sensors can significantly enhance the acquisition and selection of target objects, thereby enabling the detection of various functional molecules. In this review, we describe the mechanisms of SERS enhancement and the construction of SERS substrates. We summarize the design strategies for aptamer-based SERS technology and provide an overview of its applications in environmental pollutant detection, food safety and quality monitoring, and biomedical diagnostics. Finally, we discuss the current advantages and limitations of aptamer-based SERS sensors, as well as the vast potential for future development. This review will provide a guiding route for the development and application of novel aptamer-based sensors.

AB - Surface-enhanced Raman spectroscopy (SERS) is a powerful technique with high sensitivity, fast response, and non-destructive detection, but it faces interference from other substances in practical applications. Aptamers, as excellent affinity agents, have the capability to bind with various targets to form stable structures. The integration of aptamers into SERS sensors can significantly enhance the acquisition and selection of target objects, thereby enabling the detection of various functional molecules. In this review, we describe the mechanisms of SERS enhancement and the construction of SERS substrates. We summarize the design strategies for aptamer-based SERS technology and provide an overview of its applications in environmental pollutant detection, food safety and quality monitoring, and biomedical diagnostics. Finally, we discuss the current advantages and limitations of aptamer-based SERS sensors, as well as the vast potential for future development. This review will provide a guiding route for the development and application of novel aptamer-based sensors.

KW - Aptamer

KW - Molecular recognition

KW - Plasmonic nanostructure

KW - Sensors

KW - Surface-enhanced Raman spectroscopy (SERS)

UR - https://www.scopus.com/pages/publications/105027569911

U2 - 10.1016/j.trac.2026.118664

DO - 10.1016/j.trac.2026.118664

M3 - Review article

AN - SCOPUS:105027569911

SN - 0165-9936

VL - 196

JO - TrAC - Trends in Analytical Chemistry

JF - TrAC - Trends in Analytical Chemistry

M1 - 118664

ER -

Aptamer-engineered SERS sensors: Molecular recognition meets plasmonic enhancement for precision detection

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