Bioinspired Self-Assembled Single-Atom Iron-Based Biodegradable Supercapacitors with Intensified Capacitive Kinetics for Implantable Acupoint Electrostimulation

Haotian Pang; Chang Zhu; Yanyan Zhang; Bowen Guo; Liangru Lin; Shiwang Xie; Xinran Wang; Yixin Ding; Shiyuan Liang; Engui Wang; Peng Yin; Cong Liu; Zhou Li; Dan Luo

doi:10.1002/adfm.75184

Bioinspired Self-Assembled Single-Atom Iron-Based Biodegradable Supercapacitors with Intensified Capacitive Kinetics for Implantable Acupoint Electrostimulation

Haotian Pang
, Chang Zhu
, Yanyan Zhang
, Bowen Guo
, Liangru Lin
, Shiwang Xie
, Xinran Wang
, Yixin Ding
, Shiyuan Liang
, Engui Wang
, Peng Yin^*
, Cong Liu^*
, Zhou Li^*
, Dan Luo^*

^*此作品的通讯作者

Chinese Academy of Sciences
Capital Medical University
University of Chinese Academy of Sciences
Tsinghua University
Hunan University of Chinese Medicine
Chinese Academy of Medical Sciences

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

Biodegradable supercapacitors represent a promising alternative to conventional power sources for implantable electrical stimulation therapies. However, their development has been impeded by the lack of electrode materials that simultaneously offer high-density redox-active sites, efficient charge transport, and biocompatibility under physiological conditions. To overcome these challenges, we developed a biodegradable supercapacitor incorporating iron single-atom catalysts anchored on carbonized bioinspired self-assembled architectures (Fe SA/cBSAs). Electrochemical experiments and density functional theory (DFT) calculations revealed that the single-atom Fe sites not only introduced additional pseudocapacitance via the reversible Fe³⁺/Fe²⁺ redox pair but also weakened the Na─O interaction through surface-potential redistribution, accelerating Na⁺ desorption and diffusion. This dual mechanism—combining enhanced redox activity with weakened Na⁺ binding—intensifies capacitive kinetics to synergistically improve both faradaic and electric-double-layer charge storage efficiencies, thereby yielding a marked increase in areal capacitance, energy density, and voltage stability without compromising charge-discharge rate capability. Fabricated using a polyvinyl alcohol/phosphate-buffered saline (PVA/PBS) hydrogel electrolyte and polylactic acid (PLA) encapsulation, the device exhibited excellent biocompatibility and outstanding biodegradability in vivo. In a murine inflammatory pain model, electrical stimulation delivered at the ST36 acupoint via our biodegradable supercapacitor markedly alleviated pain behavior and reduced inflammatory markers, confirming its therapeutic potential.

源语言	英语
文章编号	e75184
期刊	Advanced Functional Materials
卷	36
期	44
DOI	https://doi.org/10.1002/adfm.75184
出版状态	已出版 - 1 6月 2026
已对外发布	是

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Pang, H., Zhu, C., Zhang, Y., Guo, B., Lin, L., Xie, S., Wang, X., Ding, Y., Liang, S., Wang, E., Yin, P., Liu, C., Li, Z., & Luo, D. (2026). Bioinspired Self-Assembled Single-Atom Iron-Based Biodegradable Supercapacitors with Intensified Capacitive Kinetics for Implantable Acupoint Electrostimulation. Advanced Functional Materials, 36(44), 文章 e75184. https://doi.org/10.1002/adfm.75184

@article{3e5da0594978497584205910d0b54135,

title = "Bioinspired Self-Assembled Single-Atom Iron-Based Biodegradable Supercapacitors with Intensified Capacitive Kinetics for Implantable Acupoint Electrostimulation",

abstract = "Biodegradable supercapacitors represent a promising alternative to conventional power sources for implantable electrical stimulation therapies. However, their development has been impeded by the lack of electrode materials that simultaneously offer high-density redox-active sites, efficient charge transport, and biocompatibility under physiological conditions. To overcome these challenges, we developed a biodegradable supercapacitor incorporating iron single-atom catalysts anchored on carbonized bioinspired self-assembled architectures (Fe SA/cBSAs). Electrochemical experiments and density functional theory (DFT) calculations revealed that the single-atom Fe sites not only introduced additional pseudocapacitance via the reversible Fe3+/Fe2+ redox pair but also weakened the Na─O interaction through surface-potential redistribution, accelerating Na+ desorption and diffusion. This dual mechanism—combining enhanced redox activity with weakened Na+ binding—intensifies capacitive kinetics to synergistically improve both faradaic and electric-double-layer charge storage efficiencies, thereby yielding a marked increase in areal capacitance, energy density, and voltage stability without compromising charge-discharge rate capability. Fabricated using a polyvinyl alcohol/phosphate-buffered saline (PVA/PBS) hydrogel electrolyte and polylactic acid (PLA) encapsulation, the device exhibited excellent biocompatibility and outstanding biodegradability in vivo. In a murine inflammatory pain model, electrical stimulation delivered at the ST36 acupoint via our biodegradable supercapacitor markedly alleviated pain behavior and reduced inflammatory markers, confirming its therapeutic potential.",

keywords = "biodegradable supercapacitor, bioinspired self-assembly, electrostimulation, implantable bioelectronics, single-atom catalyst",

author = "Haotian Pang and Chang Zhu and Yanyan Zhang and Bowen Guo and Liangru Lin and Shiwang Xie and Xinran Wang and Yixin Ding and Shiyuan Liang and Engui Wang and Peng Yin and Cong Liu and Zhou Li and Dan Luo",

note = "Publisher Copyright: {\textcopyright} 2026 Wiley-VCH GmbH.",

year = "2026",

month = jun,

day = "1",

doi = "10.1002/adfm.75184",

language = "English",

volume = "36",

journal = "Advanced Functional Materials",

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Pang, H, Zhu, C, Zhang, Y, Guo, B, Lin, L, Xie, S, Wang, X, Ding, Y, Liang, S, Wang, E, Yin, P, Liu, C, Li, Z & Luo, D 2026, 'Bioinspired Self-Assembled Single-Atom Iron-Based Biodegradable Supercapacitors with Intensified Capacitive Kinetics for Implantable Acupoint Electrostimulation', Advanced Functional Materials, 卷 36, 号码 44, e75184. https://doi.org/10.1002/adfm.75184

TY - JOUR

T1 - Bioinspired Self-Assembled Single-Atom Iron-Based Biodegradable Supercapacitors with Intensified Capacitive Kinetics for Implantable Acupoint Electrostimulation

AU - Pang, Haotian

AU - Zhu, Chang

AU - Zhang, Yanyan

AU - Guo, Bowen

AU - Lin, Liangru

AU - Xie, Shiwang

AU - Wang, Xinran

AU - Ding, Yixin

AU - Liang, Shiyuan

AU - Wang, Engui

AU - Yin, Peng

AU - Liu, Cong

AU - Li, Zhou

AU - Luo, Dan

PY - 2026/6/1

Y1 - 2026/6/1

N2 - Biodegradable supercapacitors represent a promising alternative to conventional power sources for implantable electrical stimulation therapies. However, their development has been impeded by the lack of electrode materials that simultaneously offer high-density redox-active sites, efficient charge transport, and biocompatibility under physiological conditions. To overcome these challenges, we developed a biodegradable supercapacitor incorporating iron single-atom catalysts anchored on carbonized bioinspired self-assembled architectures (Fe SA/cBSAs). Electrochemical experiments and density functional theory (DFT) calculations revealed that the single-atom Fe sites not only introduced additional pseudocapacitance via the reversible Fe3+/Fe2+ redox pair but also weakened the Na─O interaction through surface-potential redistribution, accelerating Na+ desorption and diffusion. This dual mechanism—combining enhanced redox activity with weakened Na+ binding—intensifies capacitive kinetics to synergistically improve both faradaic and electric-double-layer charge storage efficiencies, thereby yielding a marked increase in areal capacitance, energy density, and voltage stability without compromising charge-discharge rate capability. Fabricated using a polyvinyl alcohol/phosphate-buffered saline (PVA/PBS) hydrogel electrolyte and polylactic acid (PLA) encapsulation, the device exhibited excellent biocompatibility and outstanding biodegradability in vivo. In a murine inflammatory pain model, electrical stimulation delivered at the ST36 acupoint via our biodegradable supercapacitor markedly alleviated pain behavior and reduced inflammatory markers, confirming its therapeutic potential.

AB - Biodegradable supercapacitors represent a promising alternative to conventional power sources for implantable electrical stimulation therapies. However, their development has been impeded by the lack of electrode materials that simultaneously offer high-density redox-active sites, efficient charge transport, and biocompatibility under physiological conditions. To overcome these challenges, we developed a biodegradable supercapacitor incorporating iron single-atom catalysts anchored on carbonized bioinspired self-assembled architectures (Fe SA/cBSAs). Electrochemical experiments and density functional theory (DFT) calculations revealed that the single-atom Fe sites not only introduced additional pseudocapacitance via the reversible Fe3+/Fe2+ redox pair but also weakened the Na─O interaction through surface-potential redistribution, accelerating Na+ desorption and diffusion. This dual mechanism—combining enhanced redox activity with weakened Na+ binding—intensifies capacitive kinetics to synergistically improve both faradaic and electric-double-layer charge storage efficiencies, thereby yielding a marked increase in areal capacitance, energy density, and voltage stability without compromising charge-discharge rate capability. Fabricated using a polyvinyl alcohol/phosphate-buffered saline (PVA/PBS) hydrogel electrolyte and polylactic acid (PLA) encapsulation, the device exhibited excellent biocompatibility and outstanding biodegradability in vivo. In a murine inflammatory pain model, electrical stimulation delivered at the ST36 acupoint via our biodegradable supercapacitor markedly alleviated pain behavior and reduced inflammatory markers, confirming its therapeutic potential.

KW - biodegradable supercapacitor

KW - bioinspired self-assembly

KW - electrostimulation

KW - implantable bioelectronics

KW - single-atom catalyst

UR - https://www.scopus.com/pages/publications/105034753844

U2 - 10.1002/adfm.75184

DO - 10.1002/adfm.75184

M3 - Article

AN - SCOPUS:105034753844

SN - 1616-301X

VL - 36

JO - Advanced Functional Materials

JF - Advanced Functional Materials

IS - 44

M1 - e75184

ER -

Bioinspired Self-Assembled Single-Atom Iron-Based Biodegradable Supercapacitors with Intensified Capacitive Kinetics for Implantable Acupoint Electrostimulation

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